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Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients

2003; Elsevier BV; Volume: 218; Issue: 1-2 Linguagem: Inglês

10.1016/j.jns.2003.10.008

1878-5883

Dalila Camelo, Gonzalo Arboleda, Juan J. Yunis, Rodrigo Pardo, Gabriel Arango, Eugenia Solano, Luis López, Daniel Hedmont, Humberto Arboleda,

Computational Drug Discovery Methods

Polymorphisms in alpha-2-macroglobulin (A2M) and angiotensin-converting enzyme (ACE) genes have been considered as risk factors for Alzheimer's disease (AD) independently of the risk conferred by the apolipoprotein E ε4 allele (APOEε4) in diverse populations. In the present study, we have analysed the distribution of genotypes and alleles of the insertion/deletion (I/D) polymorphisms of ACE and A2M in 83 AD patients and 69 normal controls in Colombia. Our results showed that there is no association between the I/D polymorphisms of ACE and A2M with AD (P=0.788 and P=0.538, respectively). Using logistic regression and multiple correlation analysis (MCA), we confirmed that the main risk factor associated and consistently grouped with AD patients in this population is APOEε4, but this association was not observed with alleles and genotypes of ACE and A2M.