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Evolutionary and Biomedical Insights from the Rhesus Macaque Genome

2007; American Association for the Advancement of Science; Volume: 316; Issue: 5822 Linguagem: Inglês

10.1126/science.1139247

1095-9203

Richard A. Gibbs, Jeffrey Rogers, Michael G. Katze, Roger E. Bumgarner, George M. Weinstock, Elaine R. Mardis, Karin Remington, Robert L. Strausberg, J. Craig Venter, Richard K. Wilson, Mark A. Batzer, Carlos D. Bustamante, Evan E. Eichler, Matthew W. Hahn, Ross C. Hardison, Kateryna D. Makova, Webb Miller, Aleksandar Milosavljevic, Robert E. Palermo, Adam Siepel, James M. Sikela, Tony Attaway, Stephanie Bell, Kelly E. Bernard, Christian Buhay, Mimi N. Chandrabose, Marvin Dao, Clay Davis, Kimberly D. Delehaunty, Yan Ding, Huyen Dinh, Shannon Dugan-Rocha, Lucinda A. Fulton, Ramatu Ayiesha Gabisi, Toni T. Garner, Jennifer Godfrey, Alicia Hawes, Judith Hernandez, Sandra Hines, Michael Holder, Jennifer Hume, Shalini N. Jhangiani, Vandita Joshi, Ziad Khan, Ewen F. Kirkness, Andrew Cree, R. Gerald Fowler, Charles Lee, Lora Lewis, Zhangwan Li, Yih-shin Liu, Stephanie Moore, Donna M. Muzny, Lynne V. Nazareth, Dinh Ngoc Ngo, Geoffrey Okwuonu, Grace Pai, David L. Parker, Heidie A. Paul, Cynthia Pfannkoch, Craig Pohl, Yu-Hui Rogers, San Juana Ruiz, Aniko Sabo, Jireh Santibanez, Brian Schneider, Scott M. Smith, Erica Sodergren, Amanda F. Svatek, Teresa R. Utterback, Selina Vattathil, Wesley C. Warren, Courtney White, Asif Chinwalla, Yucheng Feng, Aaron L. Halpern, LaDeana W. Hillier, Xiaoqiu Huang, Pat Minx, Joanne O. Nelson, Kymberlie Pepin, Xiang Qin, Granger G. Sutton, Eli Venter, Brian P. Walenz, John W. Wallis, Kim C. Worley, Shiaw‐Pyng Yang, Steven J.M. Jones, Marco A. Marra, Mariano Rocchi, Jacqueline E. Schein, Robert Baertsch, Laura Clarke, Miklós Csürös, Jarret Glasscock, R. Alan Harris, Paul Havlak, Andrew Jackson, Huaiyang Jiang, Yue Liu, D. Messina, Yufeng Shen, Henry Song, Todd Wylie, Lan Zhang, Ewan Birney, Kyudong Han, Miriam K. Konkel, Jungnam Lee, Arian F. A. Smit, Brygg Ullmer, Hui Wang, Jinchuan Xing, Richard Burhans, Ze Cheng, John Karro, Jian Ma, Brian J. Raney, Xinwei She, Michael J. Cox, Jeffery P. Demuth, Laura Dumas, Sang-Gook Han, Janet A. Hopkins, Anis Karimpour‐Fard, Young Ho Kim, Jonathan R. Pollack, Tomáš Vinař, Charles Addo‐Quaye, Jeremiah D. Degenhardt, Alexandra Denby, Melissa J. Hubisz, Amit Indap, Carolin Kosiol, Bruce T. Lahn, Heather A. Lawson, Alison Marklein, Rasmus Nielsen, Eric J. Vallender, Andrew G. Clark, Betsy Ferguson, Ryan D. Hernandez, Kashif Hirani, Hildegard Kehrer‐Sawatzki, Jessica Kolb, Shobha Patil, Ling-Ling Pu, Yanru Ren, David Glenn Smith, David A. Wheeler, Ian Schenck, Edward V. Ball, Rui Chen, D.N. Cooper, Belinda Giardine, Fan Hsu, W. James Kent, Arthur M. Lesk, David L. Nelson, William E. O’Brien, Kay Prüfer, Peter D. Stenson, James C. Wallace, Ke HUI, Xiaoming Liu, Peng Wang, Andy Peng Xiang, Fan Yang, Galt P Barber, David Haussler, Donna Karolchik, Andy D. Kern, Robert M. Kuhn, Kayla Smith, Ann S. Zwieg,

Machine Learning in Bioinformatics

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.