Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor
1990; Elsevier BV; Volume: 31; Issue: 18 Linguagem: Inglês
10.1016/0040-4039(90)80121-2
ISSN1873-3581
AutoresGünther Wess, Kurt Keßeler, E. Baader, Wilhelm Bartmann, G. Beck, Andreas Bergmann, Heiner Jendralla, Klaus Bock, O. Holzstein, H. Peter Kleine, M. Schnierer,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoHR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated.
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