Portal de Periódicos da CAPES

Application of alicyclic β-amino acids in peptide chemistry

2006; Royal Society of Chemistry; Volume: 35; Issue: 4 Linguagem: Inglês

10.1039/b501173f

1460-4744

Ferenc Fülöp, Tamás A. Martinek, Gábor K. Tóth,

Antimicrobial Peptides and Activities

The self-organizing β-peptides have attracted considerable interest in the fields of foldamer chemistry and biochemistry. These compounds exhibit various stable secondary structure motifs that can be exploited to construct biologically active substances and nanostructured tertiary structures. The secondary structures can be controlled via the β-amino acid sequence, and cyclic β-amino acid residues play a crucial role in the design. The most important procedures for the preparation of cyclic β-amino acid monomers and peptides are discussed in this tutorial review. Besides the secondary structure design principles, the methods of folded structure detection are surveyed.