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Genome sequence of the bioplastic-producing “Knallgas” bacterium Ralstonia eutropha H16

2006; Nature Portfolio; Volume: 24; Issue: 10 Linguagem: Inglês

10.1038/nbt1244

1546-1696

Anne Pohlmann, W. Florian Fricke, Frank Reinecke, Bernhard Kusian, Heiko Liesegang, Rainer Cramm, Thomas Eitinger, Christian Ewering, Markus Pötter, Edward L. Schwartz, Axel Strittmatter, Ingo Voß, Gerhard Gottschalk, Alexander Steinbüchel, Bärbel Friedrich, Botho Bowien,

Corrosion Behavior and Inhibition

The H2-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H2 and CO2 as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(–)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility.