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BIBTEX RIS

Natural and experimental poisoning of goats with the pyrrolizidine alkaloid–producing plant Crotalaria retusa L.

2013; SAGE Publishing; Volume: 25; Issue: 5 Linguagem: Inglês

10.1177/1040638713495544

1943-4936

Lisanka Ângelo Maia, Ricardo Barbosa Lucena, Verônica Medeiros da Trindade Nobre, Antônio Flávio Medeiros Dantas, Steven M. Colegate, Franklin Riet‐Correa,

Pesticide Exposure and Toxicity

Crotalaria retusa L. (rattleweed), estimated to contain about 4.96% monocrotaline (MCT) in the seed, was associated with a natural poisoning outbreak in goats. The poisoning was experimentally reproduced by the administration of C. retusa seeds containing approximately 4.49% of MCT. Thus, 1 of 3 goats given a single dose of 5 g/kg bodyweight (bw) of seeds (248 mg MCT/kg bw) and 2 goats given a single dose of 347 mg MCT/kg bw showed acute clinical signs and were euthanized 10–11 days after dosing. Clinical signs and gross and histologic lesions were characteristic of acute centrilobular liver necrosis.