Produção Nacional
Revisado por pares
Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a Live Salmonella enterica Serovar Typhimurium Vaccine Strain
2000; American Society for Microbiology; Volume: 68; Issue: 7 Linguagem: Inglês
10.1128/iai.68.7.4349-4353.2000
ISSN1098-5522
AutoresHeloisa Guillobel, Joana Iabrudi Carinhanha, Lucia Cárdenas, John D. Clements, Darcy F. de Almeida, Luís Carlos de Souza Ferreira,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoABSTRACT Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenic Escherichia coli (ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalent Salmonella vaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT (R192G) . The results further support the adjuvant effects of LT (R192G) and represent a simple alternative to improve responses against passenger antigens expressed by orally delivered Salmonella vaccine strains.
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