Portal de Periódicos da CAPES

Are 25 SNP s from the CARDIoGRAM study associated with ischaemic stroke?

2013; Wiley; Volume: 20; Issue: 9 Linguagem: Inglês

10.1111/ene.12183

1468-1331

Håkan Lövkvist, Magnus Sjögren, Peter Höglund, Gunnar Engström, Christina Jern, Staffan Olsson, J. G. Smith, Bo Hedblad, Gunnar Andsberg, Hossein Delavaran, Katarina Jood, Ulf Kristoffersson, Bo Norrving, Olle Melander, Cecilia M. Lindgren,

Nuclear Receptors and Signaling

Background and purpose The Coronary Artery Disease Genome‐Wide Replication and Meta‐Analysis Study (CARDIoGRAM) reported 25 single‐nucleotide polymorphisms (SNPs) on 15 chromosomes to be associated with coronary artery disease ( CAD ) risk. Because common vascular risk factors are shared between CAD and ischaemic stroke ( IS ), these SNP s may also be related to IS overall or one or more of its pathogenetic subtypes. Methods We performed a candidate gene study comprising 3986 patients with IS and 2459 control subjects. The 25 CAD ‐associated SNP s reported by CARDIoGRAM were examined by allelic association analysis including logistic regression. Weighted and unweighted genetic risk scores ( GRS s) were also compiled and likewise analysed against IS . We furthermore considered the IS main subtypes large‐vessel disease ( LVD ), small‐vessel disease and cardioembolic stroke [according to Trial of Org 10172 in Acute Stroke Treatment ( TOAST )] separately. Results SNP rs4977574 on chromosome 9p21.3 was associated with overall IS [odds ratio ( OR ) = 1.12; 95% confidence interval ( CI ): 1.04–1.20; P = 0.002] as well as LVD ( OR = 1.36; 95% CI : 1.13–1.64; P = 0.001). No other SNP was significantly associated with IS or any of its main subtypes. Analogously, the GRS s did not show any noticeable effect. Conclusions Besides the previously reported association with SNP s on chromosome 9p21, this study did not detect any significant association between IS and CAD ‐susceptible genetic variants. Also, GRS s compiled from these variants did not predict IS or any pathogenetic IS subtype, despite a total sample size of 6445 participants.