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An Update on the Therapeutic Role of Alkylglycerols

2010; Multidisciplinary Digital Publishing Institute; Volume: 8; Issue: 8 Linguagem: Inglês

10.3390/md8082267

1660-3397

Tommaso Iannitti, Beniamino Palmieri,

Fatty Acid Research and Health

Scandinavian folk medicine used shark liver oil for the treatment of cancers and other ailments based on the rarity of tumors in sharks and their ability to resist infections. Shark liver oil is a source of alkylglycerols which have been studied as anti-cancer agents in several clinical trials. Moreover, alkylglycerols have been investigated for the treatment of radiation induced side effects and for their ability to boost the immune system. Several experimental studies have shown the ability of alkylglycerols to open the blood brain barrier to facilitate the access of therapeutic drugs to the central nervous system. This review covers the most important studies of alkylglycerols in both animals and humans.