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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy

2009; Elsevier BV; Volume: 34; Issue: 3 Linguagem: Inglês

10.1016/j.nbd.2009.02.018

ISSN

1095-953X

Autores

Andréy Mazarati, Don Shin, Young Se Kwon, Anatol Bragin, Eduardo Pineda, Delia L. Tio, Anna N. Taylor, Raman Sankar,

Tópico(s)

Pharmacological Effects and Toxicity Studies

Resumo

Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo-pituitary-adrenocortical (HPA) axis. We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression. Epilepsy was accompanied by the interictal elevation of plasma corticosterone, and by the positively combined dexamethasone/corticotropin releasing hormone test. The extent of the HPA hyperactivity was independent of recurrent seizures, but positively correlated with the severity of depressive behavior. We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression.

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