Biosynthesis of vitamin B 12 : Factor IV, a new intermediate in the anaerobic pathway
1996; National Academy of Sciences; Volume: 93; Issue: 25 Linguagem: Inglês
10.1073/pnas.93.25.14316
ISSN1091-6490
AutoresA. Ian Scott, Neal J. Stolowich, Jianji Wang, Oliver Gawatz, E Fridrich, Gerhard A. Müller,
Tópico(s)Neonatal Health and Biochemistry
ResumoThe structure of a novel tetradehydrocorrin, factor IV, isolated from Propionibacterium shermanii has been established by multidimensional NMR spectroscopy. Incorporation of radiolabeled factor IV into cobyrinic acid established the biointermediacy of this cobalt complex, whose structure has implications for the mechanisms of the anaerobic pathway to B 12 .
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