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BIBTEX RIS

Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript

2000; American Association for the Advancement of Science; Volume: 287; Issue: 5457 Linguagem: Inglês

10.1126/science.287.5457.1500

ISSN

1095-9203

Autores

Guey‐Chuen Perng, Clinton Jones, J. R. C. Zanella, Melissa Stone, Gail Henderson, Ada Yukht, Susan M. Slanina, Florence M. Hofman, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler,

Tópico(s)

Pharmacological Effects of Natural Compounds

Resumo

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

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