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Apoptosis‐associated gene expression in HIV‐infected patients in response to successful antiretroviral therapy

2006; Wiley; Volume: 79; Issue: 2 Linguagem: Inglês

10.1002/jmv.20768

1096-9071

Emanuela Balestrieri, Sandro Grelli, Claudia Matteucci, Antonella Minutolo, Gabriella d’Ettorre, Fiorella Di Sora, Francesco Montella, Vincenzo Vullo, Stefano Vella, Cartesio Favalli, Beatrice Macchi, Antonio Mastino,

Cell death mechanisms and regulation

Abstract The simultaneous expression of 19 apoptosis‐related genes was analyzed by RNA‐protection assay in peripheral blood mononuclear cells of HIV‐infected patients before and during successful antiretroviral therapy (ART). After 12 months of therapy, the expression of the pro‐apoptotic genes FAS , FAS‐L , FAF‐1 , FADD , CASPASE‐8 , DR3 , TRAIL , TNFR‐1 , TRADD , and BAX was significantly downregulated with respect to time 0, while that of BCL‐2 , BCL‐XL , and MCL‐1 was significantly upregulated. The data suggest that inhibition of cell death in HIV‐positive patients under successful therapy is the result of a complex network of multifactor signaling, correlated with both death and survival of lymphocytes. J. Med. Virol. 79:111–117, 2007. © 2006 Wiley‐Liss, Inc.