Water-Mediated Synthesis of 2-Substituted Benzimidazoles by Boric Acid and Glycerol
2009; CSIRO Publishing; Volume: 62; Issue: 2 Linguagem: Inglês
10.1071/ch08309
ISSN1445-0038
AutoresChhanda Mukhopadhyay, Pradip Kumar Tapaswi, Ray J. Butcher,
Tópico(s)Chemical Synthesis and Analysis
ResumoA very simple, mild, and highly efficient green catalyst has been developed for the synthesis of 2-substituted benzimidazoles by treatment of substituted ortho-phenylenediamines and aldehydes in water at 80°C in the presence of boric acid (5 mol-%) and glycerol (0.05 mL). This methodology has been standardized on 55 substrates, and nine new compounds have been synthesized.
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