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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: Clinical, cytogenetic, and molecular findings

2010; Wiley; Volume: 56; Issue: 2 Linguagem: Inglês

10.1002/pbc.22872

ISSN

1545-5017

Autores

María Sol Brassesco, Elvis Terci Valera, Régia Caroline Peixoto Lira, Lídia Alice Gomes Monteiro Marin Torres, Carlos Alberto Scrideli, Jorge Elías, Sara Reis Teixeira, Luíz Gonzaga Tone,

Tópico(s)

Tumors and Oncological Cases

Resumo

Abstract Primary lung tumors are rare in children, and mucoepidermoid carcinoma (MEC) represents less than 10% of them. Additionally, MEC arising from bronchogenic cysts (BC) is particularly unusual. We describe the clinical and genetic findings on a MEC occurring within a previous location of a BC in an adolescent. This particular association has not been previously reported. The lesion revealed normal karyotype without the typical t(11;19)(q21;p13) translocation. Cyclin D1 overexpression (165‐fold increase) was demonstrated by real‐time PCR although FISH assessment showed normal hybridization at 11q13. Information on these unusual clinical presentations may present relevant insight on tumorigenesis of infrequent pediatric pulmonary tumors. Pediatr Blood Cancer 2011;56:311–313. © 2010 Wiley‐Liss, Inc.

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