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Targeting the Oncofetal Thomsen–Friedenreich Disaccharide Using Jacalin‐PEG Phthalocyanine Gold Nanoparticles for Photodynamic Cancer Therapy

2012; Wiley; Volume: 51; Issue: 25 Linguagem: Inglês

10.1002/anie.201201468

1521-3773

Girgis Obaid, Isabelle Chambrier, Michael J. Cook, David A. Russell,

Glycosylation and Glycoproteins Research

Angewandte Chemie International EditionVolume 51, Issue 25 p. 6158-6162 Communication Targeting the Oncofetal Thomsen–Friedenreich Disaccharide Using Jacalin-PEG Phthalocyanine Gold Nanoparticles for Photodynamic Cancer Therapy† Girgis Obaid, Girgis Obaid School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this authorDr. Isabelle Chambrier, Dr. Isabelle Chambrier School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this authorProf. Michael J. Cook, Prof. Michael J. Cook School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this authorProf. David A. Russell, Corresponding Author Prof. David A. Russell d.russell@uea.ac.uk School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this author Girgis Obaid, Girgis Obaid School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this authorDr. Isabelle Chambrier, Dr. Isabelle Chambrier School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this authorProf. Michael J. Cook, Prof. Michael J. Cook School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this authorProf. David A. Russell, Corresponding Author Prof. David A. Russell d.russell@uea.ac.uk School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ (UK)Search for more papers by this author First published: 09 May 2012 https://doi.org/10.1002/anie.201201468Citations: 86 † This work was financially supported by EPSRC through a studentship for G.O. M.J.C. acknowledges the award of an Emeritus Fellowship from the Leverhulme Trust. The assistance of Dr. Colin MacDonald, Dr. Paul Thomas, and Alba Warn with the TEM, confocal microscopy, and tissue culture, respectively is gratefully acknowledged. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Light-sensitive: Targeted photodynamic therapy is achieved by using gold nanoparticles that are stabilized by a mixed monolayer of a hydrophobic zinc phthalocyanine photosensitizer, which produces cytotoxic singlet oxygen, and a water-soluble thiol-functionalized poly(ethylene glycol) carrying the lectin jacalin, which targets the Thomsen–Friedenreich disaccharide antigen at the surface of cancer cells. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201201468_sm_miscellaneous_information.pdf812.3 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume51, Issue25June 18, 2012Pages 6158-6162 RelatedInformation