Portal de Periódicos da CAPES

Antimicrobial terpenoids from Pterocarpus indicus

2005; Taylor & Francis; Volume: 19; Issue: 4 Linguagem: Inglês

10.1080/14786410410001704822

1478-6427

Consolacion Y. Ragasa, Roderick D. de Luna, Joy G. Hofileña,

Phytochemistry and Bioactive Compounds

Abstract A mixture of loliolide 1 (>85%) and paniculatadiol 2 (<15%) was obtained from the ethyl acetate leaf extract of Pterocarpus indicus by silica gel chromatography, while the air-dried flowers afforded lupeol 3 and phytol esters 4. The structures of 1–4 were determined by NMR spectroscopy. Antimicrobial tests on a mixture of 1 and 2 indicated that it has moderate activity against Candida albicans and low activity against Pseudomonas aeruginosa, Escherichia coli, and Aspergillus niger. It was found inactive against Staphylococcus aureus, Bacillus subtilis, and Trichophyton mentagrophytes. Keywords: Pterocarpus indicusLeguminosaeLoliolidePaniculatadiolLupeolPhytol estersAntimicrobial Acknowledgements The authors are very grateful to Dr. John A. Rideout for conducting the NMR analyses at the School of Chemical and Biomedical Sciences, Central Queensland University, Rockhampton, Queensland, Australia. The antimicrobial tests were conducted at the University of the Philippines-Natural Science Research Institute (UP-NSRI). Research grants from the Department of Science and Technology – Philippine Council for Advanced Science and Technology Research and Development (DOST-PCASTRD) and the University Research Coordination Office (URCO) of De La Salle University are gratefully acknowledged.