Produção Nacional
Revisado por pares
Extensive Experience and Validation of Polyethylene Glycol Precipitation as a Screening Method for Macroprolactinemia
1998; American Association for Clinical Chemistry; Volume: 44; Issue: 8 Linguagem: Inglês
10.1093/clinchem/44.8.1758
ISSN1530-8561
AutoresJosé Gilberto H. Vieira, Teresinha T. Tachibana, Leda H. Obara, Rui M. B. Maciel,
Tópico(s)Adrenal and Paraganglionic Tumors
ResumoSerum human prolactin (PRL) is heterogeneous in molecular size, with the 23-kDa monomer being the predominant form in healthy subjects and patients with prolactinomas. From the point of view of molecular size, other circulating forms include the 50-kDa dimer (big-PRL) and the 150- to 170-kDa form (big-big-PRL, or macroprolactin) (1). Recent publications have associated asymptomatic hyperprolactinemia with a predominance of macroprolactin in the circulation; this occurrence appears to be more common than previously thought (2)(3)(4) and can have obvious practical implications. The finding of a predominance of macroprolactinemia can change the focus of the evaluation of a patient, with the possible avoidance of more sophisticated and expensive imaging studies. We evaluated the polyethylene glycol (PEG) precipitation method to screen for the presence of macroprolactinemia in a large series of clinical samples. Serum PRL was measured by immunofluorometric assay (IFMA; reference range, 2–15 μg/L; Delfia, Wallac Oy), and samples with values ≥30 μg/L were studied. The value of 30 μg/L or higher, considered as …
Referência(s)