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Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model

2013; American Association for the Advancement of Science; Volume: 5; Issue: 201 Linguagem: Inglês

10.1126/scitranslmed.3005983

1946-6242

Ishita Das, Joo Min Park, Jung Hoon Shin, Soo Kyeong Jeon, Hernán Lorenzi, David J. Linden, Paul F. Worley, Roger H. Reeves,

Genomic variations and chromosomal abnormalities

In a mouse model of Down syndrome, treatment with a Sonic hedgehog agonist on the day of birth normalized cerebellar structure and improved learning and memory.