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Determination of Candesartan Cilexetil in Tablet Dosage Forms and Dissolution Testing Samples by First Derivative UV Spectrophotometric Method

2009; Taylor & Francis; Volume: 42; Issue: 14 Linguagem: Inglês

10.1080/00032710903137434

1532-236X

Naseem A. Charoo, Mohammad Ahmed Bashir, Enas Abdalla, Khalid Ibrahim Haj Ali,

Pesticide Residue Analysis and Safety

Abstract This article describes the development and validation of a first derivative UV quantitative analytical method for determination of candesartan cilexetil in tablet dosage forms. A signal at 270.1 nm of the first derivative spectrum (ID270.1) was found adequate for quantification. The limit of quantification was 3.06 µg/ml. The linearity between ID270.1 nm and concentration of candesartan cilexetil in the range of 6.00–32.00 µg/ml presented a correlation coefficient of (r2) = 0.9990. The mean recovery percentage was 100.97 and 99.23% for candesartan cilexetil standard solution and candesartan standard cilexetil solution with excipients, respectively. The intraday and interday accuracy of the assay was 98.60% and 99.10% respectively. The intraday and interday variability was below 2.0%. The proposed method is accurate, precise, sensitive, and selective and can be used in quality control laboratories for its intended purpose. Keywords: Candesartan cilexetilfirst derivative spectrophotometrytablet dosage form Notes The Standard error of the slope is 9.46e–06. The Standard error of the intercept is 0.0002052. The square correlation (r2) = 0.9990. The regression standard deviation Sy\x RMSE = 0.00021. Linear regression equation is; ID270.1 = −0.0006862 concentration + (−0.0008371). LOD = 0.92 µg/ml. LOQ = 3.06 µg/ml.