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Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.

1984; American Society for Clinical Investigation; Volume: 73; Issue: 1 Linguagem: Inglês

10.1172/jci111185

1558-8238

Giulio Gabbiani, Olivier Kocher, W S Bloom, Joël Vandekerckhove, K. Weber,

Protease and Inhibitor Mechanisms

Actin of smooth muscle cells of rat and human aortic media shows a predominance of the alpha-isoform. In experimental rat aortic intimal thickening, in human atheromatous plaque, and in cultured aortic smooth muscle cells, there is a typical switch in actin expression with a predominance of the beta-form and a noticeable amount of gamma-form. This pattern of actin expression represents a new reliable protein-chemical marker of experimental and human atheromatous smooth muscle cells.