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Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides.

1978; Rockefeller University Press; Volume: 148; Issue: 4 Linguagem: Inglês

10.1084/jem.148.4.1081

1540-9538

Gabriel P. Haas, Arthur G. Johnson, A. Nowotny,

Monoclonal and Polyclonal Antibodies Research

The experiments described herein demonstrate the plaque-forming cell response of C3H/HeJ mice can be suppressed by a Boivin type lipopolysaccharide (LPS) and a deproteinized glycolipid. Suppression was observed both in vivo and in vitro, and could be transferred to normal cells in coculture experiments. This newly discovered effect of LPS in C3H/HeJ mice indicates that the adjuvant and inhibitory action of LPS may be distinct phenomena which are under different genetic regulation. Thus, the C3H/HeJ strain provides a convenient animal model for study of immunosuppression independent of the adjuvant effect.