Effects of acacia honey on wound healing in various rat models
2009; Wiley; Volume: 24; Issue: 4 Linguagem: Inglês
10.1002/ptr.2990
ISSN1099-1573
AutoresFarida Iftikhar, Muhammad Arshad, Faiza Rasheed, D. Amraiz, Anwar P. P. Abdul Majeed, Muhammad Gulfraz,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoHoney is a traditional remedy for the treatment of infected wounds, and is becoming more important as microbial resistance to conventional therapeutic agents increases. A study was conducted to assess the wound-healing activity of Acacia honey using incision, excision, burn and dead-space wound models in rats. Different formulations of honey were used and rats were treated topically as well as orally. Both the higher and lower doses of honey produced a significant effect on healing (p < 0.05). The area of epithelization was found to increase, followed by an increase in wound contraction, skin-breaking strength, tissue granulation. The hydroxyproline content also increased in the rats treated with higher doses of honey compared to control, indicating an increase in collagen formation.
Referência(s)