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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Vascular endothelial growth factor and thymidine phosphorylase expression in salivary gland tumors with distinct metastatic behavior

2010; Wiley; Volume: 40; Issue: 6 Linguagem: Inglês

10.1111/j.1600-0714.2010.00980.x

ISSN

1600-0714

Autores

Paulo Rogério de Faria, Roberto A. Lima, Fernando Luiz Dias, Paulo Antônio Silvestre de Faria, Ana Lúcia Amaral Eisenberg, Kelen Christine do Nascimento Souza, Sérgio Vitorino Cardoso, Adriano Mota Loyola,

Tópico(s)

Vascular Tumors and Angiosarcomas

Resumo

J Oral Pathol Med (2010) 40: 456–459 Background: Metastasis of salivary gland tumors has a negative impact on survival. Angiogenesis and its factors are potential markers for predicting metastasis in different malignant tumors, but this is not the case for salivary gland tumors. Methods: Salivary gland tumors of distinct biologic behavior were analyzed according to the semiquantitative immunoexpression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP). Results: Vascular endothelial growth factor expression was predominantly weak in benign tumors. Weak TP expression was observed in 100% cases of benign tumors and in 74.3% of primary malignant tumors. High VEGF and TP expression levels were significantly associated with primary malignant tumors but not with primary non-metastasizing and primary metastasizing malignant tumors or with subtypes of malignant tumors. Conclusions: Vascular endothelial growth factor and TP expression levels discriminate benign and malignant tumors but cannot predict metastasis from non-metastasizing tumors.

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