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Pathogenic Mechanisms of Depression in Multiple Sclerosis

2011; American Psychiatric Association Publishing; Volume: 23; Issue: 3 Linguagem: Inglês

10.1176/jnp.23.3.jnp261

1545-7222

Joe John Vattakatuchery, Hugh Rickards, Andrea E. Cavanna,

Fibromyalgia and Chronic Fatigue Syndrome Research

This article reviews various theories and findings on mechanisms of depression in MS, describing the latest research approaches, as they relate to theories of disease-process. The authors have compiled data on lesion location, extensity, and severity; the effects of immune dysfunction and side effects of immunomodulatory drugs, including interferon therapy; and psychosocial stressors as they all relate to the common symptom of depression in MS.