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Neural input and neural control of the subcommissural organ

2001; Wiley; Volume: 52; Issue: 5 Linguagem: Inglês

10.1002/1097-0029(20010301)52

1097-0029

A. J. Jim�nez, Pedro Fernández‐Llebrez, Jose Manuel P�rez-F�gares,

Neuroscience of respiration and sleep

Microscopy Research and TechniqueVolume 52, Issue 5 p. 520-533 Topical PaperFree Access Neural input and neural control of the subcommissural organ Antonio J. Jiménez, Corresponding Author Antonio J. Jiménez ajjimenez@uma.es Departamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Málaga, SpainDepartamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain, E-29071Search for more papers by this authorPedro Fernández-Llebrez, Pedro Fernández-Llebrez Departamento de Biología Animal, Facultad de Ciencias, Universidad de Málaga, Málaga, SpainSearch for more papers by this authorJose Manuel Pérez-Fígares, Jose Manuel Pérez-Fígares Departamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Málaga, SpainSearch for more papers by this author Antonio J. Jiménez, Corresponding Author Antonio J. Jiménez ajjimenez@uma.es Departamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Málaga, SpainDepartamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain, E-29071Search for more papers by this authorPedro Fernández-Llebrez, Pedro Fernández-Llebrez Departamento de Biología Animal, Facultad de Ciencias, Universidad de Málaga, Málaga, SpainSearch for more papers by this authorJose Manuel Pérez-Fígares, Jose Manuel Pérez-Fígares Departamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Málaga, SpainSearch for more papers by this author First published: 23 February 2001 https://doi.org/10.1002/1097-0029(20010301)52:5 3.0.CO;2-6Citations: 18AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The neural control of the subcommissural organ (SCO) has been partially characterized. The best known input is an important serotonergic innervation in the SCO of several mammals. In the rat, this innervation comes from raphe nuclei and appears to exert an inhibitory effect on the SCO activity. A GABAergic innervation has also been shown in the SCO of the rat and frog Rana perezi. In the rat, GABA and the enzyme glutamate decarboxylase are involved in the SCO innervation. GABA is taken up by some secretory ependymocytes and nerve terminals, coexisting with serotonin in a population of synaptic terminals. Dopamine, noradrenaline, and different neuropeptides such as LH-RH, vasopressin, vasotocin, oxytocin, mesotocin, substance P, α-neoendorphin, and galanin are also involved in SCO innervation. In the bovine SCO, an important number of fibers containing tyrosine hydroxylase are present, indicating that in this species dopamine and/or noradrenaline-containing fibers are an important neural input. In Rana perezi, a GABAergic innervation of pineal origin could explain the influence of light on the SCO secretory activity in frogs. A general conclusion is that the SCO cells receive neural inputs from different neurotransmitter systems. In addition, the possibility that neurotransmitters and neuropeptides present in the cerebrospinal fluid may also affect the SCO activity, is discussed. Microsc. Res. Tech. 52:520–533, 2001. © 2001 Wiley-Liss, Inc. Citing Literature Volume52, Issue5Special Issue: The Subcommissural Organ. Cellular, Molecular, Physiological and Pathological Aspects1 March 2001Pages 520-533 ReferencesRelatedInformation