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Oxidative stress and anti-oxidative defense in schoolchildren residing in a petrochemical industry environment

2009; Springer Science+Business Media; Volume: 47; Issue: 3 Linguagem: Inglês

10.1007/s13312-010-0045-y

0974-7559

Ana Vujović, Jelena Kotur‐Stеvuljevic, D. Kornic, Slavica Spasić, Vesna Spasojević‐Kalimanovska, Nataša Bogavac‐Stanojević, Aleksandra Stefanović, Marija Deanović, Sofika Babka, Bosiljka Aleksic, Zorana Jelić‐Ivanović,

Medical and Biological Ozone Research

To evaluate the possible relationship between industrial air pollution and oxidative stress in schoolchildren by comparing parameters from children residing in two nearby localities with contrasting environmental conditions. 42 schoolchildren (12–15 years) from Pancevo (site of Serbia's largest petrochemical installation) formed the exposed group. 82 schoolchildren from Kovacica village, located 30 km north of Pancevo, formed the non-exposed group. Oxidative stress status, anti-oxidative defense parameters, paraoxonase-1 status, lipid status, glucose concentration and leukocyte counts were compared in two groups. The children from Pancevo showed higher level of oxidative stress demonstrated by an elevated malondialdehyde concentration (P <0.001) and decreased superoxide dismutase activity (P<0.01) in comparison to the non-exposed group. The results suggested a relationship between the presence of air pollutants and increased oxidative stress in schoolchildren residing in an industrial environment.