Artigo Acesso aberto Revisado por pares

Hypervitaminosis a: A liver lover's lament

1988; Lippincott Williams & Wilkins; Volume: 8; Issue: 2 Linguagem: Inglês

10.1002/hep.1840080237

ISSN

1527-3350

Autores

Maria A. Leo, Charles S. Lieber,

Tópico(s)

Alcohol Consumption and Health Effects

Resumo

HepatologyVolume 8, Issue 2 p. 412-417 EditorialFree Access Hypervitaminosis a: A liver lover's lament Maria Anna Leo, Maria Anna Leo Section of Liver Disease and Nutrition, Alcohol Research & Treatment Center, Bronx VA Medical Center and Mount Sinai School of Medicine (CUNY), New York, New York 10468Search for more papers by this authorCharles S. Lieber M.D., Corresponding Author Charles S. Lieber M.D. Section of Liver Disease and Nutrition, Alcohol Research & Treatment Center, Bronx VA Medical Center and Mount Sinai School of Medicine (CUNY), New York, New York 10468Alcohol Research and Treatment Center, Veterans Administration Medical Center, 130 West Kingsbridge Road, Bronx, New York 10463===Search for more papers by this author Maria Anna Leo, Maria Anna Leo Section of Liver Disease and Nutrition, Alcohol Research & Treatment Center, Bronx VA Medical Center and Mount Sinai School of Medicine (CUNY), New York, New York 10468Search for more papers by this authorCharles S. Lieber M.D., Corresponding Author Charles S. Lieber M.D. Section of Liver Disease and Nutrition, Alcohol Research & Treatment Center, Bronx VA Medical Center and Mount Sinai School of Medicine (CUNY), New York, New York 10468Alcohol Research and Treatment Center, Veterans Administration Medical Center, 130 West Kingsbridge Road, Bronx, New York 10463===Search for more papers by this author First published: March/April 1988 https://doi.org/10.1002/hep.1840080237Citations: 79AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Sommer A. Nutritional blindness: xerophtalmia and keratomalacia. New York: University Press Oxford, 1982. 2 Underwood BA, Siegel H, Weisell RC. et al. Liver stores of vitamin A in a normal population dying suddenly or rapidly from unnatural causes in New York City. Am J Clin Nutr 1970 23: 1037–1042. 3 Raica N Jr, Scott J, Lowry L. Vitamin A concentration in human tissues collected from five areas in the United States. Am J Clin Nutr 1972; 25: 291–296. 4 Sommer A, Tarwotjo I, Djunadedi ME. et al. Oral versus intramuscular vitamin A in the treatment of xerophtalmia. Lancet 1980 1: 557–559. 5 McClain CJ, Van Thiel DH, Parker S, et al. Alteration in zinc, vitamin A and retinol-binding protein in chronic alcoholics: a possible mechanism for night blindness and hypogonadism. Alcoholism: Clin Exp Res 1979; 3: 135–140. 6 Russell RM, Morrison SA, Smith FR. et al. 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Hepatic and dermatologic manifestations of chronic hypervitaminosis A in adults. Am J Med 1986; 80: 491–496. 42 Babb RR, Kieraldo JJ. Cirrhosis due to hypervitaminosis A. West J Med 1970; 128: 244–246. 43 Carpenter TO, Pettifor JM, Russell RM, et al. Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake. J Pediatr 1987; 111: 507–512. 44 Leo MA, Lieber CS. New pathway for retinol metabolism in liver microsomes. J Biol Chem 1985; 260: 5228–5231. 45 Leo MA, Kim C, Lieber CS. NAD+-dependent retinol dehydrogenase in liver microsomes. Arch Biochem Biophys 1987; 259: 241–291. 46 Schurr D, Herbert J, Habibi E, et al. Case report: unusual presentation of vitamin A intoxication. J Pediatr Gastroenterol Nutr 1983; 2: 705–707. 47 Leo MA, Arai M, Sato M, et al. Hepatotoxicity of moderate vitamin A supplementation in the rat. Gastroenterology 1982; 82: 194–205. 48 Worner TM, Gordon G, Leo MA. et al. Treatment with vitamin A of sexual dysfunction in male alcoholics. Am J Clin Nutr 1988 (in press). 49 Leo MA, Lieber CS. Hepatic fibrosis after long term administration of ethanol and moderate vitamin A supplementation in the rat. Hepatology 1983; 3: 1–11. 50 Mak KM, Leo MA, Lieber CS. Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells. Gastroenterology 1984; 87: 188–200. 51 Mallia AK, Smith JE, Goodman DWS. Metabolism of retinol binding protein and vitamin A during hypervitaminosis A in the rat. J Lipid Res 1975; 16: 180–188. 52 Smith FR, Goodman US. Vitamin A transport in human vitamin A toxicity. N Engl J Med 1976; 294: 805–808. 53 Sato M, Lieber CS. Increased metabolism of retinoic acid after chronic ethanol consumption in rat liver microsomes. Arch Biochem Biophys 1982; 213: 557–564. 54 Leo MA, Iida S, Lieber CS. Retinoic acid metabolism by a system reconstituted with cytochrome P-450. Arch Biochem Biophys 1984; 234: 305–312. 55 Oikarinen H, Oikarinen AI, Tan EML. et al. Modulation of procollagen gene expression by retinoids. J Clin Invest 1985 75: 1545–1553. 56 Senoo H, Wake K. Suppression of experimental hepatic fibrosis by administration of vitamin A. Lab Invest 1985; 52: 182–194. 57 Leo MA, Lowe N, Lieber CS. Decreased hepatic vitamin A after drug administration in men and rats. Am J Clin Nutr 1984; 40: 1131–1136. 58 Leo MA, Lowe N, Lieber CS. Potentiation of ethanol-induced hepatic vitamin A depletion by phenobarbital and butylated hydroxytoluene. J Nutr 1987; 117: 70–76. 59 Olson JA. Adverse effects of large doses of vitamin A and retinoids. Semin Oncol 1983; 10: 290–293. 60 Howard W, Willhite CC. Toxicity of retinoids in humans and animals. J Toxicol-Toxin Rev 1986; 5: 55–94. 61 Heywood R, Palmer AK, Gregson RL. et al. The toxicity of betacarotene. Toxicity 1985 36: 91–100. 62 Tuchweber B, Garb DB, Hatakeyama S. Prevention of hypervitaminosis A by spironolactone and anabolic steroids. Int J Vit Res 1970; 40: 575–584. 63 Pitha J, Szente L. Rescue from hypervitaminosis A or potentiation of retinoid toxicity by different modes of cyclodextrin administration. Life Sci 1983; 32: 719–723. 64 Leo MA, Lieber CS. Hepatic vitamin A depletion in alcoholic liver injury in man. N Engl J Med 1982; 307: 597–601. 65 Sato M, Lieber CS. Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats. J Nutr 1981; 111: 2015–2023. 66 Sato M, Lieber CS. Changes in vitamin A status after acute ethanol administration in the rat. J Nutr 1982; 112: 1188–1196. 67 Leo MA, Kim C, Lieber CS. Increased vitamin A in esophagus and other extrahepatic tissues after chronic ethanol consumption in the rat. Alcoholism: Clin Exp Res 1986; 10: 487–492. Citing Literature Volume8, Issue2March/April 1988Pages 412-417 ReferencesRelatedInformation

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