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Vitamin A Supplementation and Genital Shedding of Herpes Simplex Virus among HIV‐1–Infected Women: A Randomized Clinical Trial

2004; Oxford University Press; Volume: 189; Issue: 8 Linguagem: Inglês

10.1086/383049

1537-6613

Jared M. Baeten, R. Scott McClelland, Lawrence Corey, Julie Overbaugh, Ludo Lavreys, Barbra A. Richardson, Anna Wald, Kishorchandra Mandaliya, Job J. Bwayo, Joan K. Kreiss,

Retinoids in leukemia and cellular processes

Cross-sectional analyses have associated vitamin A deficiency with genital shedding of herpes simplex virus (HSV) among human immunodeficiency virus type 1 (HIV-1)-infected women. A randomized clinical trial of vitamin A supplementation given daily for 6 weeks was conducted among 376 women in Mombasa, Kenya, who were coinfected with HSV-2 and HIV-1. At follow-up, there was no significant difference in the detection of genital HSV DNA between women receiving vitamin A supplementation and women receiving placebo (40% vs. 44%, respectively; P = .5) Among women shedding HSV, there was no significant difference in the mean HSV DNA quantity between the group that received vitamin A supplementation and the group that received placebo (4.51 vs. 4.67 log10 copies/swab; P = .6). HSV shedding was associated with significantly higher vaginal and cervical HIV-1 shedding, even after controlling for the plasma HIV-1 load and the CD4 count. Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity.