Factor XII inhibition reduces thrombus formation in a primate thrombosis model
2014; Elsevier BV; Volume: 123; Issue: 11 Linguagem: Inglês
10.1182/blood-2013-04-499111
ISSN1528-0020
AutoresAnton Matafonov, Philberta Y. Leung, Adam E. Gailani, Stephanie L. Grach, Cristina Puy, Qiufang Cheng, Mao-fu Sun, Owen J. T. McCarty, Erik I. Tucker, Hiroaki Kataoka, Thomas Renné, James H. Morrissey, András Gruber, David Gailani,
Tópico(s)Platelet Disorders and Treatments
ResumoKey Points Factor XII can contribute to thrombus formation in human and nonhuman primate blood. An antibody that blocks factor XII activation (15H8) produces an antithrombotic effect in a primate thrombosis model.
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