Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole l -Riboside 1263W94
2001; American Society for Microbiology; Volume: 8; Issue: 6 Linguagem: Inglês
10.1128/cdli.8.6.1279-1281.2001
ISSN1098-6588
AutoresJames J. McSharry, Ann McDonough, Betty Olson, Christine L. Talarico, M G Davis, Karen K. Biron,
Tópico(s)Toxoplasma gondii Research Studies
ResumoABSTRACT The average 50% inhibitory concentration (IC 50 ) values for AD169 were 0.22 ± 0.09 μM 1263W94 and 5.36 ± 0.12 μM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC 50 was 0.42 ± 0.09 μM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC 50 was 3.78 ± 1.62 μM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.
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