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Invasive Gram-negative bacilli are frequently resistant to standard antibiotics for children admitted to hospital in Kilifi, Kenya

2005; Oxford University Press; Volume: 56; Issue: 1 Linguagem: Inglês

10.1093/jac/dki145

1460-2091

Philip Bejon, Isaiah Mwangi, Caroline Ngetsa, Salim Mwarumba, James A. Berkley, Brett Lowe, Kathryn Maitland, Kevin Marsh, Mike English, J. Anthony G. Scott,

Antibiotic Use and Resistance

Objectives: To determine the pattern of resistance among Gram-negative bacilli causing invasive bacterial disease for the antibiotics that are already in common use in Kilifi, Kenya and for two potential alternatives, ciprofloxacin and cefotaxime. Also, to determine whether prevalence and severity of resistance was increasing over time, to identify patients who are particularly at risk of resistant infections, and to explore which factors are associated with the development of resistance in our setting.