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Effect of smoking history on outcome of patients diagnosed with TB and HIV

2014; European Respiratory Society; Volume: 45; Issue: 3 Linguagem: Inglês

10.1183/09031936.00160714

1399-3003

Koen Vanden Driessche, Monita R. Patel, Nana Mbonze, Martine Tabala, Marcel Yotebieng, Frieda Behets, Annelies Van Rie,

Hepatitis C virus research

Tobacco use, infection with HIV and active tuberculosis (TB) are important public health problems worldwide. Smoking affects susceptibility to TB, with an increased risk of infection, TB disease and TB death [1, 2]. An estimated 1.1 million of the 8.6 million people who developed TB in 2012 were HIV-positive [3]. It has been estimated that smoking could cause 18 million excess cases of TB and 40 million excess deaths between 2010 and 2050 [4], but little is known about the effect of smoking on the outcomes of people receiving care for both HIV and TB. Among TB–HIV patients on antiretrovirals those who smoke(d) are more likely to have adverse TB treatment outcomes The authors thank the participating healthcare workers. Without their enthusiasm and dedication, this work could not have been carried out. We thank S. Mpuate (School of Public Health, University of Kinshasa, Kinshasa, DR Congo) and E. Cromwell (Dept of Epidemiology, University of North Carolina, Chapel Hill, NC, USA) for assistance in preparing the ITART dataset and J. Bettinger (Vaccine Evaluation Center, University of British Columbia, Vancouver, BC, Canada) for helpful discussions.