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Synthesis, structural characterization and cytotoxic activity of organotin derivatives of indomethacin

2008; Wiley; Volume: 22; Issue: 3 Linguagem: Inglês

10.1002/aoc.1366

1099-0739

C. Camacho-Camacho, Irma Rojas‐Oviedo, M. Angeles Paz‐Sandoval, Jorge Cárdenas, Rubén A. Toscano, Marcel Gielen, Lidia Barrón Sosa, Francisco Sánchez Bártez, Isabel Gracia‐Mora,

Synthesis and Reactivity of Sulfur-Containing Compounds

Abstract The synthesis, characterization and cytotoxic properties in vitro of tri‐ n ‐butyltin 1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetate ( 1 ), tri‐phenyltin 1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetate ( 2 ), tetra‐ n ‐butyltin[bis‐1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetato]distannoxane ( 3 ) and di‐ n ‐butyltin bis‐1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetate ( 4 ) are described. These compounds have been characterized by 1 H, 13 C and 119 Sn NMR spectroscopy in solution and 119 Sn NMR in the solid state, infrared spectroscopy, elemental analysis and X‐ray diffraction for compound 1 . The growth inhibition effects of compounds 1–4 against the lung adenocarcinoma cell line SK‐LU‐1 as well as the cervical cancer cell line HeLa were determined. Compounds 1 and 2 exhibit cytotoxic activity, whereas compounds 3 and 4 are inactive. Copyright © 2008 John Wiley & Sons, Ltd.