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Possible role of serotoninergic system in the neurobehavioral impairment induced by acute methylmercury exposure in zebrafish (Danio rerio)

2011; Elsevier BV; Volume: 33; Issue: 6 Linguagem: Inglês

10.1016/j.ntt.2011.08.006

1872-9738

Caio Maximino, Juliana Araújo, Luana Ketlen Reis Leão, Alan Barroso Araújo Grisólia, Karen Renata Matos Oliveira, Mônica Gomes Lima, Evander de Jesus Oliveira Batista, Maria Elena Crespo‐López, Amauri Gouvêia, Anderson Manoel Herculano,

Nitric Oxide and Endothelin Effects

Adult zebrafish were treated acutely with methylmercury (1.0 or 5.0 μg g− 1, i.p.) and, 24 h after treatment, were tested in two behavioral models of anxiety, the novel tank and the light/dark preference tests. At the smaller dose, methylmercury produced a marked anxiogenic profile in both tests, while the greater dose produced hyperlocomotion in the novel tank test. These effects were accompanied by a decrease in extracellular levels of serotonin, and an increase in extracellular levels of tryptamine-4,5-dione, a partially oxidized metabolite of serotonin. A marked increase in the formation of malondialdehyde, a marker of oxidative stress, accompanied these parameters. It is suggested that methylmercury-induced oxidative stress produced mitochondrial dysfunction and originated tryptamine-4,5-dione, which could have further inhibited tryptophan hydroxylase. These results underscore the importance of assessing acute, low-level neurobehavioral effects of methylmercury.