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Distal Convoluted Tubule

2014; Lippincott Williams & Wilkins; Volume: 9; Issue: 12 Linguagem: Inglês

10.2215/cjn.05920613

1555-905X

Arohan R. Subramanya, David H. Ellison,

Ion channel regulation and function

The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.