Synthesis of Polysubstituted Dihydropyridines by Four-Component Reactions of Aromatic Aldehydes, Malononitrile, Arylamines, and Acetylenedicarboxylate
2010; American Chemical Society; Volume: 12; Issue: 16 Linguagem: Inglês
10.1021/ol101475b
ISSN1523-7060
AutoresJing Sun, Er‐Yan Xia, Qun Wu, Chao‐Guo Yan,
Tópico(s)Synthesis and Characterization of Pyrroles
ResumoA practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter. This four-component reaction is atom-efficient, high-yielding, and applicable to a wide variety of four-component reactions.
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