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Association between clinical complete response and pathological complete response after preoperative chemoradiation in patients with gastroesophageal cancer: analysis in a large cohort

2012; Elsevier BV; Volume: 24; Issue: 5 Linguagem: Inglês

10.1093/annonc/mds617

1569-8041

Naga Cheedella, Akihiro Suzuki, Lianchun Xiao, Wayne L. Hofstetter, Dipen M. Maru, Takashi Taketa, Kazuki Sudo, Mariela A. Blum, Steven H. Lin, Jonathan Welch, J. H. Lee, Manoop S. Bhutani, David C. Rice, Ara A. Vaporciyan, Stephen G. Swisher, Jaffer A. Ajani,

Pancreatic and Hepatic Oncology Research

BackgroundChemoradiation followed by surgery is the preferred treatment of localized gastroesophageal cancer (GEC). Surgery causes considerable life-altering consequences and achievement of clinical complete response (clinCR; defined as postchemoradiation [but presurgery] endoscopic biopsy negative for cancer and positron emission tomographic (PET) scan showing physiologic uptake) is an enticement to avoid/delay surgery. We examined the association between clinCR and pathologic complete response (pathCR).Patients and methodsTwo hundred eighty-four patients with GEC underwent chemoradiation and esophagectomy. The chi-square test, Fisher exact test, t-test, Kaplan–Meier method, and log-rank test were used.ResultsOf 284 patients, 218 (77%) achieved clinCR. However, only 67 (31%) of the 218 achieved pathCR. The sensitivity of clinCR for pathCR was 97.1% (67/69), but the specificity was low (29.8%; 64/215). Of the 66 patients who had less than a clinCR, only 2 (3%) had a pathCR. Thus, the rate of pathCR was significantly different in patients with clinCR than in those with less than a clinCR (P < 0.001).ConclusionsclinCR is not highly associated with pathCR; the specificity of clinCR for pathCR is too low to be used for clinical decision making on delaying/avoiding surgery. Surgery-eligible GEC patients should be encouraged to undergo surgery following chemoradiation despite achieving a clinCR.