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A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

2015; Royal Society of Chemistry; Volume: 6; Issue: 3 Linguagem: Inglês

10.1039/c4sc03239j

2041-6539

Michael Beck, Shin Bi Oh, Richard A. Kerr, Hyuck Jin Lee, Sohee Kim, Sujeong Kim, Milim Jang, Brandon T. Ruotolo, Joo‐Yong Lee, Mi Hee Lim,

Heavy Metal Exposure and Toxicity

An in vivo chemical tool designed to target metal−Aβ complexes and modulate their activity was applied to the 5XFAD mouse model of Alzheimer’s disease (AD) demonstrating the involvement of metal−Aβ in AD pathology.