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Intermolecular rhodium-catalyzed [2 + 2 + 2] carbocyclization reactions of 1,6-enynes with symmetrical and unsymmetrical alkynes

2005; Royal Society of Chemistry; Issue: 31 Linguagem: Inglês

10.1039/b505383h

1364-548X

P. Andrew Evans, James R. Sawyer, Kwong Wah Lai, John C. Huffman,

Cyclopropane Reaction Mechanisms

The crossed intermolecular rhodium-catalyzed [2 + 2 + 2] carbocyclization of carbon and heteroatom tethered 1,6-enynes can be accomplished with symmetrical and unsymmetrical alkynes, to afford the corresponding bicyclohexadienes in an efficient and highly selective manner.