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In vivo degradation of silicones

1993; Wiley; Volume: 29; Issue: 6 Linguagem: Inglês

10.1002/mrm.1910290620

1522-2594

Leoncio Garrido, Bettina Pfleiderer, Mikhail Papisov, Jerome L. Ackerman,

Advanced NMR Techniques and Applications

Abstract 29 Si nuclear magnetic resonance (NMR) spectroscopy is applied to study the degradation of polysiloxanes (silicones) in vivo. Our results with animal models show that silicone migrates from the implant to the liver ( 29 Si resonance at −20 ppm) and new silicon containing compounds form after the silicones are introduced into the rats. The new 29 Si resonances in the chemical shift range of −40 to −85 ppm are related to hydrolyzed silicone, those at −90 to −115 ppm are indicative of the presence of silica (SiO 2 ), and the peaks observed at −120 to −150 are related to high coordinated silicon complexes. These resonances are not present in the 29 Si spectra of the silicones before implantation. Our findings demonstrate that silicones are not metabolically inert.