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The “Thrifty Genotype” in 19981

2009; Oxford University Press; Volume: 57; Issue: 5 Linguagem: Inglês

10.1111/j.1753-4887.1999.tb01782.x

1753-4887

James V. Neel,

Diet, Metabolism, and Disease

eases and their pathophysiology, and review the arguments for regarding the genetic predisposition to all three of these conditions as formerly adaptive genotypes, the functioning of which is now compromised by the changing lifestyles of the technologically advanced nations. Finally, we will discuss the probable relative effectiveness in the future of a genetically based in contrast to an environmentally based program of prevention and therapy for these diseases.