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Prediction of protein-protein interactions by combining structure and sequence conservation in protein interfaces

2005; Oxford University Press; Volume: 21; Issue: 12 Linguagem: Inglês

10.1093/bioinformatics/bti443

1367-4811

Ali Selim Aytuna, Attila Gürsoy, Özlem Keskin,

Computational Drug Discovery Methods

Motivation: Elucidation of the full network of protein–protein interactions is crucial for understanding of the principles of biological systems and processes. Thus, there is a need for in silico methods for predicting interactions. We present a novel algorithm for automated prediction of protein–protein interactions that employs a unique bottom-up approach combining structure and sequence conservation in protein interfaces.