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Activity of posaconazole in the treatment of central nervous system fungal infections

2005; Oxford University Press; Volume: 56; Issue: 4 Linguagem: Inglês

10.1093/jac/dki288

1460-2091

Punnee Pitisuttithum, Ricardo Negroni, John R. Graybill, Beatriz Bustamante, Peter G. Pappas, Stanley W. Chapman, R S Hare, C. Hardalo,

Infectious Diseases and Mycology

Objectives: A multinational, multicentre, open-label clinical trial was conducted to evaluate the safety and efficacy of posaconazole, an extended-spectrum triazole antifungal agent, in subjects with invasive fungal infections who had refractory disease or who were intolerant of standard antifungal therapy. In this subanalysis, we report on those subjects in this trial who had a fungal infection that involved the CNS.