G/A 1947 polymorphism in catechol‐ O ‐methyltransferase (COMT) gene in Parkinson's disease
1997; Wiley; Volume: 12; Issue: 3 Linguagem: Inglês
10.1002/mds.870120325
ISSN1531-8257
AutoresTao Xie, S.L. Ho, L. S. W. Li, O. C. K.,
Tópico(s)RNA regulation and disease
ResumoAbstract High and low catechol‐ O ‐methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine 108 polymorphism associated with polymorphic G/A 1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.
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