A study of the abortifacient effect of oxymetholone in early gestation
1975; Elsevier BV; Volume: 11; Issue: 6 Linguagem: Inglês
10.1016/0010-7824(75)90063-3
ISSN1879-0518
AutoresPaul F. Brenner, Daniel R. Mishell,
Tópico(s)Reproductive Health and Contraception
ResumoOxymetholone, a steroid which inhibits progesterone synthesis, was given to 6 women in early pregnancy to produce abortions. Patients were less than 7 weeks pregnant; duration since last menstrual period was less than 46 days when therapy started. Dosage varied from 50 mg daily for 7 days to 100 mg 3 times a day for 10 days. Serum HCG, progesterone, and estradiol levels were measured before, during, and after therapy. Also total serum proteins, albumin, globulin, total bilirubin, direct bilirubin, alkaline phosphatase, SGOT, SGPT, and complete blood counts were obtained before and immediately after treatment. All determinations were normal, including the hormones. No abortions resulted from the therapy although some vaginal bleeding was noted by 3 patients. Nausea, vomiting, or abdominal pain were side effects in 4. Results indicate that oxymetholone is an ineffective agent for termination of early pregnancy.
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