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Learning to find your way: a role for the human hippocampal formation

1996; Royal Society; Volume: 263; Issue: 1377 Linguagem: Inglês

10.1098/rspb.1996.0255

1471-2954

Eleanor A. Maguire, R. S. J. Frackowiak, Chris Frith,

Child and Animal Learning Development

Restricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Maguire E. A. , Frackowiak R. S. J. and Frith C. D. 1996Learning to find your way: a role for the human hippocampal formationProc. R. Soc. Lond. B.2631745–1750http://doi.org/10.1098/rspb.1996.0255SectionRestricted accessArticleLearning to find your way: a role for the human hippocampal formation E. A. Maguire Google Scholar Find this author on PubMed Search for more papers by this author , R. S. J. Frackowiak Google Scholar Find this author on PubMed Search for more papers by this author and C. D. Frith Google Scholar Find this author on PubMed Search for more papers by this author E. A. Maguire Google Scholar Find this author on PubMed , R. S. J. Frackowiak Google Scholar Find this author on PubMed and C. D. Frith Google Scholar Find this author on PubMed Published:22 December 1996https://doi.org/10.1098/rspb.1996.0255AbstractThe importance of the hippocampal formation of the brain for allocentric spatial mapping of the environment has been suggested by animal lesion and electrophysiological work. Here we describe a positron emission tomography (PET) study designed to investigate the regional cerebral blood flow changes associated with topographical memory formation in humans, i. e. the formation of representations of largescale environments necessary for way-finding. Topographical learning of an urban environment from viewing of film footage depicting navigation was associated with activation of the right parahippocampal gyrus and hippocampus, with activation also of the left parahippocampal gyrus. In addition, there was activity in the precuneus. In contrast, the encoding of non-navigation episodic memory in a similar real-world context was not associated with activity in the hippocampal formation. Our results shed light on the neural basis of the human representation of large-scale space, pinpointing a particular role for the human hippocampal formation in learning to find one's way.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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