Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites
2005; Oxford University Press; Volume: 21; Issue: 9 Linguagem: Inglês
10.1093/bioinformatics/bti315
ISSN1367-4811
AutoresAlasdair T. R. Laurie, Robert M. Jackson,
Tópico(s)Enzyme Structure and Function
ResumoMotivation: Identifying the location of ligand binding sites on a protein is of fundamental importance for a range of applications including molecular docking, de novo drug design and structural identification and comparison of functional sites. Here, we describe a new method of ligand binding site prediction called Q-SiteFinder. It uses the interaction energy between the protein and a simple van der Waals probe to locate energetically favourable binding sites. Energetically favourable probe sites are clustered according to their spatial proximity and clusters are then ranked according to the sum of interaction energies for sites within each cluster.
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