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Staying in touch: the molecular era of organelle contact sites

2011; Elsevier BV; Volume: 36; Issue: 11 Linguagem: Inglês

10.1016/j.tibs.2011.08.004

1362-4326

Yael Elbaz‐Alon, Maya Schuldiner,

Ion channel regulation and function

Membrane contact sites (MCS) are close appositions between two organelles that facilitate both signaling and the passage of ions and lipids from one cellular compartment to another. Despite the fact that MCS have been observed for over 50 years now, we still know very little about the molecular machinery required to create them or their structure, function and regulation. In this review, we focus on the three best-characterized contact sites to date: the nucleus–vacuole junction and mitochondria–ER and plasma membrane–ER contact sites. In addition, we discuss principles arising from recent research and highlight several unanswered questions in the field. Membrane contact sites (MCS) are close appositions between two organelles that facilitate both signaling and the passage of ions and lipids from one cellular compartment to another. Despite the fact that MCS have been observed for over 50 years now, we still know very little about the molecular machinery required to create them or their structure, function and regulation. In this review, we focus on the three best-characterized contact sites to date: the nucleus–vacuole junction and mitochondria–ER and plasma membrane–ER contact sites. In addition, we discuss principles arising from recent research and highlight several unanswered questions in the field.