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Distribution of HLA class II alleles among Spanish patients with pemphigus vulgaris

1998; Wiley; Volume: 52; Issue: 3 Linguagem: Inglês

10.1111/j.1399-0039.1998.tb03043.x

1399-0039

M.F. González‐Escribano, G. Jiménez, Klaudia Walter, Matthieu Montès, A.M. Pérez-Bernal, M.R. Rodrı́guez, Julián Sánchez Conejo‐Mir, Antonio Núñez‐Roldán,

Platelet Disorders and Treatments

Abstract: Twenty‐six unrelated Spanish Caucasian individuals affected by pemphigus vulgaris (PV) were HLA typed and frequencies compared with those of 200 ethnically matched healthy controls. Twenty‐three out of 26 patients were HLA‐DR4. The frequency of HLA‐DR14 was also increased (31%; controls: 4%). Of the 23 patients positive for HLA‐DR4, 21 carried the DRB1*0402 allele. Therefore, the frequency of HLA‐DRB1*0402 among patients was 81% (4% in controls; P =4.7times 10 ‐27 , OR=100.8). Interestingly, HLA‐DR13, a frequent HLA‐DR specificity in the Spanish general population (27%), was absent among the PV patients ( P =0.009; P c =0.1; OR=0.05). Taking together these data, we can conclude that, in the Spanish population, PV is preferentially and strongly associated with HLA‐DRB1*0402, whereas DRB1*13 seems to confer a protective effect in our population.